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What is the IDEXX CBC?

We are proud to introduce the IDEXX CBC, which delivers the most advanced haemogram available, including a comprehensive automated CBC result with red blood cell indicies, platelet indices, and a 5-part white cell differential.

The inclusion of absolute reticulocyte counts on all canine and feline CBCs, facilitates the diagnosis and differentiation of anaemias. Additionally the inclusion of Retic-HGB facilitates the determination of iron availability for erythropoiesis for improved patient outcomes. The 5-part white cell differential, plus identification of band neutrophils, will help accurately classify leucograms, and aid in the identification of inflammation. The use of the most current technology also allows optimal identification of platelets.

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How to Access the IDEXX CBC?

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Frequently asked questions

What is included in a Standard IDEXX CBC?

The Standard IDEXX CBC is the appropriate and most cost-effective option for routine preanaesthetic or preventive care screenings on clinically healthy animals. This option provides an automated CBC, inclusive of red cell indices, 5-part white cell differential, platelets, platelet indices, as well as an absolute reticulocyte count and reticulocyte haemoglobin (Retic-HGB) reported on all canine and feline patients.

A blood film review is automatically included when results are outside the acceptance criteria.

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What is included in a Comprehensive IDEXX CBC?

The Comprehensive IDEXX CBC is inclusive of an automated CBC with 5-part white blood cell differential, platelets, platelet indices, as well as absolute reticulocyte count and reticulocyte haemoglobin (Retic-HGB). A blood film review is automatically performed when results are outside the acceptance criteria.

In addition to the Standard, the Comprehensive IDEXX CBC provides an IDEXX pathologist interpretation to evaluate the significance of the haematology findings.

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What are reticulocytes and why are they important?

Reticulocytes are immature red blood cells that do not have a nucleus. The lifespan of a reticulocyte is 1 – 2 days in circulation.

Their presence in circulation is used to differentiate regenerative from nonregenerative anaemia. Reticulocytosis in the absence of anaemia may be an indication of significant underlying disease accompanied by RBC loss or destruction with an adequate regenerative response (compensated anaemia), or may reflect a physiological response, or occasionally a developing erythrocytosis. Reticulocytes should be evaluated along with the reticulocyte haemoglobin (Retic-HGB) for early detection of blood loss and inflammatory conditions prior to the development of anaemia.

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What is the benefit of trending reticulocytes?

Trending reticulocytes can help create a patient baseline and in turn help with the review of historical results and spot trends quickly if there is an increase or decrease outside of the normal reference interval. If a patient has consistently had a reticulocytosis when blood has been collected, and the haematocrit (HCT) is stable, it is most likely a physiological response. If there is a reticulocytosis with a reducing HCT, then underlying haemorrhage or haemolysis is more likely.

VetConnect PLUS will trend results in a line graph over time which makes it easier to spot abnormalities.

Visit VetConnect PLUS to view your patient's trending results.

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What is reticulocyte haemoglobin (Retic-HGB)?

Reticulocyte haemoglobin (Retic-HGB), is the iron-containing oxygen transport protein inside reticulocytes. Retic-HGB reflects iron availability for developing erythrocytes and red blood cell function.

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What is the benefit of tracking haemoglobin in reticulocytes?

As reticulocytes have a maturity cycle of 1 - 2 days circulating in the blood before they mature into adult RBCs, tracking the haemoglobin quality in these immature RBCs can give an indicator as to the iron availability for red blood cell production.

Determining the Retic-HGB concentration is important to know if the reticulocytes are developing sufficiently in the bone marrow and if they have reached their full oxygen carrying capacity. Retic-HGB is a sensitive and early indicator of decreased iron availability. If a patient has a low Retic-HGB quantity, this can be caused by blood loss or inflammatory conditions.

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What is a band neutrophil?

A band neutrophil is an immature white blood cell (WBC), which is either not present or is present in very low numbers in the blood circulation of healthy patients. When band neutrophils are identified in the blood it is an indicator that the bone marrow has been signaled to release more WBCs, usually as part of an inflammatory response. A higher level of band neutrophils points toward a more severe inflammatory response. Neutrophils are usually released from the bone marrow once mature, so to see band neutrophils in the blood should signal the vet to investigate why.

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What is a left shift and what value is this to a patient?

A left shift is the term used to indicate that there are immature WBCs present in the blood. In the blood, you should normally see mature WBCs or segmented neutrophils. The left shift describes the production releasing a neutrophil lifecycle left of a mature neutrophil.

Band Neutrophils are an early parameter of inflammation, with their identification in the circulation allowing earlier diagnostic testing and therapy.

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